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Research News | Drug News | Conference News
Does Epigenetic Methylation Shut Down Dying Motor Neurons?
November 21, 2011
Like the caretaker of a condemned building shutting off the lights for the last time, DNA methyltransferases shut off motor neuron genes during apoptosis...
Research Brief: Dexpramipexole Results Look Promising for ALS
November 20, 2011
Dexpramipexole, a candidate drug for amyotrophic lateral sclerosis, seems to have aced its Phase 2 test...
DC: New ALS Genetics Hog the Limelight at Satellite Conference
November 18, 2011
Researchers studying amyotrophic lateral sclerosis and other diseases related to RNA-binding proteins are excited about new genes recently identified in ALS...
The Good, the Bad, and the Fractious? Ligand’s Role in Brain
November 16, 2011
Microglia have a split personality in neurodegenerative disease—sometimes good, ...
Potential Therapeutic Target for ALS Discovered
November 15, 2011
The connection between ALS and inflammation is strengthened by the finding that TDP-43 interacts with the p65 subunit of the inflammatory protein NF-kB p65 in the spinal cords of ALS patients. Researchers propose that TDP-43 and p65 act together to influence microglia cells to initiate an inflammatory response that may lead to the death of spinal cord neurons. In a mouse model of ALS, treatment with an agent capable of blocking p65 activity minimized neuron loss and eased disease symptoms.
Research News has been provided in partnership with alzforum.org |
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