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Does TDP-43 Oligomerize and Coax Aβ to Do the Same?
September 27, 2014

TDP-43 self-assembles into oligomers that are able to recruit Aβ to form oligomers of its own, claims a paper in the September 12 Nature Communications. Using a new TDP-43 oligomer antibody, the authors report binding in postmortem brain samples from people who had frontotemporal dementia....

Twin Study Suggests Environment Modifies Genetic Risk for ALS
September 19, 2014

Twins who came to an ALS Clinic in Toronto were identical down to the repeats in their C9ORF72 genes, except one had amyotrophic lateral sclerosis and the other did not. The mismatch suggests environmental influences modified the twins’ risk for ALS, researchers concluded in the September...

Ataxin 2 Variants Take Aim at Motor Neurons, Not Frontal Cortex
September 15, 2014

Oversized nucleotide repeat expansions in two genes, ataxin 2 and C9ORF72, boost carriers’ risk for amyotrophic lateral sclerosis, frontotemporal dementia, or a combination of both. The discovery of these two disease genes inspired clinicians around the globe to count repeats in their...

Method to Identify Modified Protein Structures has Diagnostic Potential for Neurodegenerative Diseases
September 14, 2014
Researchers from the ETH in Zurich, Switzerland and University of Padua, Italy, have developed a new technique to identify conformational changes in proteins in complex biological samples, such as blood or cerebrospinal fluid...

After a Summer of Icy Showers, What Will Happen with Buckets of Cash for ALS?
September 12, 2014

In the viral video craze of the summer, millions of people dumping freezing water on their heads generated an unexpected deluge of more than $100 million to support amyotrophic lateral sclerosis charities. The ALS Association took in $112 million between...

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