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Do High Blood Pressure Meds Reduce the Risk of ALS?
November 21, 2014

Medications that reduce blood pressure are associated with fewer cases of amyotrophic lateral sclerosis, according to an epidemiological study in the November 10 JAMA Neurology online. Researchers from Kaohsiung Medical University in Kaohsiung City, Taiwan, mined that nation’s health...

EphA4 Proteases Regulate Spinal Motor Axon Guidance
November 12, 2014
Key proteins and molecular pathways during nervous system development often emerge later in life as important mediators of neurodegenerative disease. One such example is the ephrin receptor EphA4, which provides guidance signals to help developing axons reach their final cellular targets, and was recently identified as a modifier gene in ALS...

Geriatric Astrocytes Fail Motor Neurons in ALS Model
November 7, 2014
Older people can get a boost from the vigor and vitality of youngsters. Aging cells may enjoy a similar benefit. Motor neurons survive longer when surrounded by young astrocytes, according to a paper in press in Neurobiology of Aging. In contrast, older astrocytes make a feeble support...

Twin-derived iPSCs Shed Light on Parkinson’s Disease
November 6, 2014
Monozygotic twins discordant for a neurodegenerative disease provide a rare opportunity to delve into the genetic and non-genetic contributors to disease pathophysiology (See Sept 2014 news for a recent story on insights from twins discordant for C9ORF72 ALS). Using induced pluripotent stem cell (iPSC)-derived dopaminergic neurons from monozygotic twins discordant for Parkinson’s disease (PD), a team of researchers from the New York Stem Cell Foundation Research Institute have created a unique model of Parkinson’s disease (PD) in a dish...

Blood Test for Alzheimer’s Disease Enables Presymptomatic Diagnosis
October 31, 2014
A major obstacle to identifying effective and disease-modifying therapies for ALS is the long delay between initial onset of symptoms and diagnosis. The earlier the diagnosis, the earlier patients could receive therapeutic interventions to attenuate or potentially reverse neuronal damage. A new early diagnostic blood test for Alzheimer’s disease (AD) is a major advance in that direction...

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