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Multiple Mutations Hasten ALS Onset, Suggests Genetic Study
November 27, 2014

The genomes of people with amyotrophic lateral sclerosis, even so-called sporadic cases, are often blemished by rare variants that may increase risk for the disease. Some unlucky folk tote two or even three of these potential risk alleles, and they develop the disease a decade earlier...

New Evidence for Role of Upper Motor Neurons in Disease Onset and Spinal Motor Neuron Survival in ALS
November 25, 2014
In mouse models of ALS, motor neuron death in the spinal cord and denervation at the neuromuscular junction (NMJ) are evident prior to onset of behavioral symptoms, but the timing of upper motor neuron (UMN) degeneration and its contribution to disease is not well understood...

Mathematical Models Adopted from Cancer Shed Light on Causes of ALS
November 25, 2014
Despite being very different diseases, ALS and some forms of cancer have shared characteristics: complex genetics, mostly frequently adult onset, followed by rapid disease progression...

Do High Blood Pressure Meds Reduce the Risk of ALS?
November 21, 2014

Medications that reduce blood pressure are associated with fewer cases of amyotrophic lateral sclerosis, according to an epidemiological study in the November 10 JAMA Neurology online. Researchers from Kaohsiung Medical University in Kaohsiung City, Taiwan, mined that nation’s health...

EphA4 Proteases Regulate Spinal Motor Axon Guidance
November 12, 2014
Key proteins and molecular pathways during nervous system development often emerge later in life as important mediators of neurodegenerative disease. One such example is the ephrin receptor EphA4, which provides guidance signals to help developing axons reach their final cellular targets, and was recently identified as a modifier gene in ALS...

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