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Matrin 3: New Genetic Mutation Further Implicates RNA Processing Defects in ALS
March 31, 2014
A new ALS-associated genetic mutation has been identified, further implicating defects in RNA processing in ALS disease pathology....

Microglial NF-κB Regulates ALS Disease Progression in Mouse Model
March 26, 2014
Microglia, macrophages of the brain and spinal cord, are critical for protecting the central nervous system against invading pathogens. However, they are also central contributors to neuroinflammation and motor neuron death in ALS...

A New Approach for Generating Muscle Cells from Human Stem Cells
March 21, 2014
A study published on March 21 in Stem Cells Translational Medicine reports on a new method for generating large numbers of skeletal muscle cells and myogenic progenitors from human embryonic stem cells (hESC)...

Don’t Forget to Switch REST On
March 19, 2014
In a surprise re-appearance, the regulatory gene repressor element 1-silencing transcription factor (REST) has been found to re-emerge in the aging brain and protect it from a variety of stressors. It was previously thought that REST is expressed only in the developing brain, where it represses neuronal genes by modifying chromatin structure...

Pseudobulbar Affect is Common in Older ALS Patients
March 18, 2014
Uncontrollable outbursts of crying and laughter in neurologic disorders are termed pseudobulbar affect (PBA). PBAs are thought to occur due to injury to pathways that regulate emotional expression, and are a secondary consequence of several neurological disorders...





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