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Bioinformatics Identifies Eight Master Regulators of ALS Neurodegeneration
July 2, 2015
During amyotrophic lateral sclerosis, motor neurons can fall victim to toxic secretions from the astrocytes that are supposed to support them. As scientists puzzle...
Could Extra Granulins Be the Problem in Progranulin Insufficiency?
June 26, 2015
People with only one good copy of progranulin typically develop frontotemporal dementia (FTD), leading scientists to suspect that a half-dose of progranulin is...
Short Expansions May Predispose Offspring to ALS
June 25, 2015
The most common cause of familial ALS is the expansion of a non-coding hexanucleotide repeat in the C9ORF72 gene (see Sept 2011 news). But how many GGGGCC repeats are necessary...
No C9ORF72, No Problem: Knockout Mouse Neurologically OK
June 19, 2015
Mice missing both copies of the amyotrophic lateral sclerosis gene C9ORF72 balance and move just fine, and their neurons exhibit no signs of degeneration. The...
ALS Model Worms Sicken Via Innate Immune Pathway
June 17, 2015
In the motor neurons of the humble nematode, researchers have found a link between motor neuron degeneration and an ALS gene. Scientists from the Université de...




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