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SOD1 Aggregation Dynamics Correlate with ALS Clinical Phenotypes
October 17, 2014
Over 100 mutations in the SOD1 protein have been linked to ALS, but how all these distinct mutations lead to the same disease is still a matter of debate. A new study published October 14 in Proceedings of the National Academy of Sciences applied sophisticated biophysical methods to examine how mutations in the SOD1 protein affect protein stability and aggregation dynamics...

More Data, More Progress: ALS Researchers Debut Shared Database
October 17, 2014
Thanks to an enormous effort to collect and comingle data from 17 ALS clinical studies, researchers can now access thousands of patient records to understand the disease’s natural progression, hunt for biomarkers, and plan better therapeutic trials. Project organizers from the nonprofit Prize4Life in Cambridge, Massachusetts, and the Neurological Clinical Research Institute at Massachusetts General Hospital (MGH) in Boston, describe the Pooled Resource Open-Access ALS Clinical Trials database (PRO-ACT) in the October 8 Neurology online...

ALS, Parkinson’s Proteins Co-Mingle in Mitochondria Destruction Pathway
October 10, 2014

Researchers have linked genes for amyotrophic lateral sclerosis and Parkinson’s disease in the same pathway, a cellular mechanism to degrade decrepit mitochondria. Scientists already knew that the PD genes parkin and PTEN-induced putative kinase 1 (Pink1) were important in this process,...

Evidence Mounts That Mitochondrial Gene Is Bona Fide ALS, FTD Risk Factor
October 3, 2014

Just three months after a paper outed a gene for a mitochondrial protein as a potential cause of amyotrophic lateral sclerosis-frontotemporal dementia, four new publications have made the case clear. CHCHD10 is an ALS/FTD spectrum gene. A handful of different mutations in the gene whose...

ALSA Commits an Initial $21.7 Million of Ice Bucket Donations to Fund New Research Initiatives
October 2, 2014
The ALS Association (ALSA) received over $100 million in donations this summer as the Ice Bucket Challenge swept across the U.S. and abroad (see Sept 2014 news story). The ALSA has responded to the urge of the ALS research and patient communities to expeditiously fund critical new research programs, and announced on October 2 an initial commitment of $21.7 million...

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